Trusted Medical collaborates with Yale School of Medicine to conduct evidence-based healthcare research. Together, we operate the full clinical research lifecycle in collaboration with PWA-approved organizations.
In the UNRAVEL study, the Yale study group is measuring Lp(a) levels in people from various backgrounds across the U.S. to see how it affects heart health. Lp(a) is a type of fat like LDL cholesterol, often called “bad cholesterol.” High Lp(a) levels can cause plaque buildup and narrow blood vessels, increasing the risk of heart disease. These levels usually stay the same over time and can run in families. Knowing your risk can help you and your loved ones take steps to lower it with medications.
If you join the study, you’ll fill out health questionnaires and connect your electronic health records (EHRs) securely. You will also attend have blood draw appointment to measure your Lp(a) free of cost.
As a participant in the UNRAVEL Study, you will learn valuable information about your heart health. After your blood draw, you can share your results with your doctor to discuss any changes to your medications or lifestyle that might help protect your heart. Since Lp(a) levels stay fairly constant, one test can give valuable insights for your long-term care. Plus, you will be helping important research on heart disease treatments that could benefit your family and others in the community.
Eligible participants must be age 18 years or older, live in the United States, and have a medically confirmed diagnosis of ASCVD, with documentation in EHRs at the time of any study procedure or event. In our study, a diagnosis of ASCVD will include:
Those who are willing to participate in the consent process, online pre-screening questionnaire, and EHR data connection through Hugo Connect will be eligible to be selected for the study. Participants must have an active email account and phone number for ongoing communication with the UNRAVEL Study coordinators. All participants must live within a reasonable distance of a Quest Diagnostics center.
The study seeks participants who identify as belonging to any of these racial or ethnic groups: Hispanic, non-Hispanic Black, non-Hispanic South Asian, or non-Hispanic White. Non-Hispanic South Asians will be defined as individuals with ancestry from Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, or Sri Lanka.
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